Abstract: Objective: The clinical distribution and drug resistance of 128 strains of Streptococcus pneumoniae （SPN）were investigated
in the First Affiliated Hospital of Dali University in order to provide more reliable basis for clinical medication. Methods: The clinical
distribution and drug sensitive tests of 128 strains of SPN were retrospectively analyzed from March 2017 to March 2018 in the First
Affiliated Hospital of Dali University. MIC value was used to analyze the drug sensitivity, and WHONET 5.6 software was used for
statistic analysis. Results: 128 strains of SPN were mainly found from the Department of Pediatrics（53.90%）, and mainly from sputum
specimens（89.06%）. The susceptible population was mainly infants（39.06%）and elderly（25.00%）. The drug resistance rate of SPN
to penicillin was 33.59%, and the drug resistance rate of erythromycin, tetracycline and trimethoprim/sulfamethoxazole were more than
70%. SPN has higher sensibility to levofloxacin, ofloxacin, chloramphenicol, cefotaxime and amoxicillin with rate of more than 80%. No
vancomycin, ertapenem, moxifloxacin, rina thiazole amine and telithromycin drug resistant strain was found. Conclusion: The SPN was
mainly isolated from infants and the senior people. More attention should be paid to the result of the drug sensibility to direct clinical
rational and moderate use of antibiotics for patients in order to reduce production of SPN drug-resistant strains.

Key words: Streptococcus pneumoniae, clinical distribution, drug resistance